Basic principles of molecular diagnostics

Gene (DNA) carries all the mysteries of life, and molecular diagnosis is the golden key to the precision medicine industry. Molecular diagnosis can realize individual genome analysis and provide personalized diagnosis, which is far superior to other diagnostic methods in accuracy and information density. Molecular diagnosis is to obtain the nucleic acid sequence of the gene by analyzing the base pair of the gene, to determine whether the gene sample has been mutated, and to help diagnose and avoid certain diseases.

Molecular diagnostic technology platform

Molecular diagnosis has the following technology platforms: PCR (amplification technology), FISH (fluorescence in situ hybridization), gene chip and gene sequencing. Among them, PCR technology is mainly to amplify and detect extremely low concentrations of DNA; FISH is mainly based on probes and fluorescein to detect specific gene fragments; and gene chips can detect multiple gene targets at one time; gene sequencing is Detect gene sequences in longer dimensions.

The status quo of the industry chain of molecular diagnostics

The upstream of the molecular diagnostic industry chain is mainly raw material suppliers, including biological products such as diagnostic enzymes, primers, reversal enzymes, probes, high-purity sodium chloride, absolute ethanol and other fine chemicals, and extraction media materials; the middle stream is mainly diagnostic equipment Suppliers of consumables and reagents include Roche, Thermo Fisher, Daan Gene, Kehua Biology, Zhijiang Biology, etc. The downstream is mainly users who use instruments or reagents, including hospitals, third-party medical laboratories, blood stations, physical examination centers, etc. .