Pyrosequencer is applied in clinical and experimental gene sequencing, espcially in clinical precised medicine.

Pyrosequencing is  unqiue in rapid , precised and low cost. Unlike next-generational and other sequnecing techniques, prosequencing is most suitable for various clonical application:

1, Individualized Pharmacogenetic Assay

Pharmacogenomics(PGx) is  to evaluate response or side-effect of medicine before patients are ordered. Medicine response/side effects are different among different patients, based on the difference absorbance, metabolism, receptor, clearance.  All these key pathways of medicine are mainly decided by difference in genesequences. So it is reasonable to decide a medicine is effective or may cause side-effects befor a medicine is ordered to patient with pharmacogenetic tests.

With rapid development of pharmacogenetics, more than 800 medicined are required by FDA to perform pharmacogentic test before prescription. More and more medicines will be performed pharmacogenetic test for patients' safety and effectiveness.

Pharmacogenetic test is performed mainly by PCR, pyrosequencing and next-generation sequencing. Pyroesquencing is superior to other techqiques  for it is easy, quick, cheap and accurate,which is especially fit for clinical demand.

2, DNA methylation assay

3,Microbiome and drug-resistance test